Active Solicitation · DEPARTMENT OF HEALTH AND HUMAN SERVICES
AI Summary
The Advanced Research Projects Agency for Health (ARPA-H) is soliciting proposals for the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. This initiative aims to enhance ICU health outcomes by addressing immuno-inflammatory dysregulation. Proposals are due by May 28, 2026, with a Proposer's Day on March 11, 2026.
The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement. CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure. Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and its Attachments A F. Proposer's Day: Wednesday, March 11, 2026 (ARPA-H-SN-26-149) Solution Summaries Due: Monday, March 30, 2026, 1 PM ET (to https://solutions.arpa-h.gov) Questions Due: Friday, May 22, 2026, 1 PM ET (to https://solutions.arpa-h.gov/Ask-A-Question/) Full Proposals Due: Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov) ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete. -------------------------- Amendment 1 -------------------------- The purpose of this amendment is to: change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H. -------------------------- Amendment 2 -------------------------- The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO) is a federal acquisition solicitation issued by DEPARTMENT OF HEALTH AND HUMAN SERVICES. Review the full description, attachments, and submission requirements on SamSearch before the response deadline.
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