Active Solicitation · DEPT OF DEFENSE

    Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

    Sol. DARPA-SN-26-67Special NoticeARLINGTON, VA
    Open · 21d remaining
    DAYS TO CLOSE
    21
    closes Jun 24, 2026
    POSTED
    May 18, 2026
    Publication date
    NAICS CODE
    541714
    Primary industry classification
    PSC CODE
    AC11
    Product & service classification

    AI Summary

    The Defense Advanced Research Projects Agency (DARPA) is seeking innovative proposals for the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) project. This opportunity focuses on developing novel mechanisms for modifying epigenetic base modifications in DNA, aiming to enhance understanding of DNA-protein interactions and applications of epigenetic modifications.

    Contract details

    Solicitation No.
    DARPA-SN-26-67
    Notice Type
    Special Notice
    Posted Date
    May 18, 2026
    Response Deadline
    June 24, 2026
    NAICS Code
    541714AI guide
    PSC / Class Code
    AC11
    Contract Code
    97AE
    Primary Contact
    Dr. Aric Lu, DARPA/BTO
    State
    VA
    ZIP Code
    222032114
    AI Product/Service
    service

    Description

    UPDATE: The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.

    Key dates

    1. May 18, 2026Posted Date
    2. June 24, 2026Proposals / Responses Due

    AI search tags

    Frequently asked questions

    Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) is a federal acquisition solicitation issued by DEPT OF DEFENSE. Review the full description, attachments, and submission requirements on SamSearch before the response deadline.

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