Closed Solicitation · DEPARTMENT OF HEALTH AND HUMAN SERVICES
AI Summary
The National Institutes of Health is soliciting proposals for a product that measures over 5,400 human proteins using Proximity Extension Assay technology. The product must demonstrate high specificity, a broad dynamic range, and low sample volume requirements, making it suitable for advanced medical research and epidemiology studies.
Requirements: 2.0 BACKGROUND Our lab studies the role of inflammation/innate resistance and commensal microbiota in carcinogenesis, cancer progression and therapy of cancer. The following product features/characteristics are required for this requirement: Protein Coverage - Measures ~5,400+ human proteins simultaneously in a single workflow. Technology - Uses Proximity Extension Assay (PEA) with dual antibody recognition coupled to DNA barcoding and next-generation sequencing (NGS) readout. Sample input requires only 2 ul of plasma, serum, and other sample types Specificity - Reported 99.5% specificity with negligible cross-reactivity due to dual-recognition antibody design. Dynamic Range - Approximately 10 orders of magnitude (fg/mL to mg/mL), enabling detection of both low- and high-abundance proteins. Key strengths Very broad proteome coverage while maintaining antibody-based specificity. Excellent sensitivity for low-abundance circulating proteins (especially cytokines and signaling proteins). Extremely low sample-volume requirement. Highly standardized platform, making it attractive for epidemiology and multi-omics studies.
Olink Explorer >5400 is a federal acquisition solicitation issued by DEPARTMENT OF HEALTH AND HUMAN SERVICES. Review the full description, attachments, and submission requirements on SamSearch before the response deadline.
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